Cerezyme® (imiglucerase for injection) is administered by intravenous infusion over 1 to 2 hours. Dosage should be individualized to each patient. Initial dosages range from 2.5 units/kg of body weight 3 times a week to 60 units/kg once every 2 weeks. 60 units/kg every 2 weeks is the dosage for which the most data are available.^[1]

For more information about Cerezyme therapy and dosing, please see the full product information (PDF).

Administration support materials

To review the steps required to prepare and administer Cerezyme, you may order the Cerezyme Reconstitution and Administration (R&A) guide and video, which offer complete instructions for these procedures.

Download a PDF copy of the Reconstitution & Administration Guide.

To view PDFs, you must have Adobe Acrobat^® Reader^®. To download this software for free, click here.

Go to Request Materials to order the printed guide and video.

To enhance patient convenience and aid therapeutic compliance, Genzyme offers an Infusion Scheduler tool that can assist the treating physician in outlining a schedule for patients to track infusions.

Important Safety Information

Adverse reactions related to Cerezyme® (imiglucerase for injection) administration have been reported in less than 15% of patients. Each of the following events occurred in less than 2% of the total patient population. Reported adverse events include nausea, vomiting, abdominal pain, diarrhea, rash, fatigue, headache, fever, dizziness, chills, backache, and tachycardia. Adverse events associated with the route of administration include discomfort, pruritus, burning, swelling or sterile abscess at the site of venipuncture. Symptoms suggestive of hypersensitivity include anaphylactoid reaction, pruritus, flushing, urticaria, angioedema, chest discomfort, dyspnea, coughing, cyanosis and hypotension. Approximately 15% of patients have developed IgG antibodies; periodic monitoring is suggested. Side effects should be reported promptly to Genzyme Medical Information at 800-745-4447, option 2. To learn more, please see full product information (PDF), or contact Genzyme at 1-800-745-4447.

1. Prescribing Information for Cerezyme® (imiglucerase for injection).