With 17 years of history of effectiveness in controlling and reversing many of the effects of Type 1 Gaucher disease, Cerezyme has been prescribed for more than 5,600 patients in more than 90 countries around the world.
- Has been demonstrated to reverse many of the blood and organ-related symptoms of Type 1 Gaucher disease such as anemia (low red blood cell count), thrombocytopenia (low blood platelet count), bone disease, and hepatomegaly or splenomegaly (enlarged liver or spleen)
- Is supported by 17 years of clinical data and experience
- Is backed by Genzyme’s comprehensive educational programs, insurance reimbursement support, and clinical research
Cerezyme has shown the positive impact that treatment can have on many manifestations of the disease. Data generated by the Gaucher Registry, a database of clinical information sponsored and administered by Genzyme, have yielded insights that have shaped how doctors and patients manage Gaucher disease. For example, it has been observed in Registry data that Cerezyme therapy decreased the frequency of bone pain and bone crises (severe bone pain), and improved bone mineral density in patients with documented skeletal disease.
Genzyme developed Cerezyme in 1994 in cooperation with the National Institutes of Health. Today, Genzyme is a global leader in research and product development for Gaucher disease and other lysosomal storage disorders.
Indication & Usage
Cerezyme® (imiglucerase for injection) is indicated for long-term enzyme replacement therapy for pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions:
- anemia (low red blood cell count)
- thrombocytopenia (low blood platelet count)
- bone disease
- hepatomegaly or splenomegaly (enlarged liver or spleen)
Important Safety Information
Approximately 15% of patients have developed immune responses (antibodies). These patients have a higher risk of an allergic reaction (hypersensitivity). Use Cerezyme® (imiglucerase for injection) carefully if you have had an allergic reaction to the product in the past. Symptoms suggestive of allergic reaction happened in 6.6% of patients, and include anaphylactoid reaction (a serious allergic reaction), itching, flushing, hives, an accumulation of fluid under the skin, chest discomfort, shortness of breath, coughing, cyanosis (a bluish discoloration of the skin due to diminished oxygen), and low blood pressure.
Side effects related to Cerezyme administration have been reported in less than 15% of patients. Each of the following events occurred in less than 2% of the total patient population. Reported side effects include nausea, abdominal pain, vomiting, diarrhea, rash, fatigue, headache, fever, dizziness, chills, backache, and rapid heart rate. Because Cerezyme therapy is administered by intravenous infusion, reactions at the site of injection may occur: discomfort, itching, burning, swelling or uninfected abscess. Cerezyme is available by prescription only. For more information, consult your physician.
Please see Full Prescribing Information (PDF).