The Treatment Experience
What to know when starting treatment with Cerezyme
- Cerezyme is given by intravenous (IV) infusion
- This is a process that involves injecting the drug into a vein, directly into the bloodstream
- Cerezyme is a long-term treatment for the non-CNS symptoms of Gaucher disease types 1 and 3. Your body requires regular infusions to reduce GL-1 build-up in cells that can lead to Gaucher disease symptoms
Considerations during treatment with Cerezyme
- The recommended dosage of Cerezyme based upon disease severity ranges from 2.5 units per kilogram 3 times a week to 60 units per kilogram once every 2 weeks
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- Your doctor will determine your Cerezyme dose and frequency
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- Your infusion time may vary based on your body weight and how you respond to treatment
- Cerezyme infusions may last over 1-2 hours and can be completed in a variety of settings, such as a doctor’s office, a treatment center, or in some cases, at home
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- During your infusion, you can do things like read a book, talk on the phone, listen to music, visit with friends or family members who are with you—even take a nap, if you wish
Regular tests to check your progress
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- Certain tests may be required to check your progress and provide a way for your doctor to gain insight into the status of your disease and disease-management plan
- Your doctor will decide which tests you need and how frequently you need them
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- These tests may include assessments of your spleen and liver, blood, and bones
Navigating the treatment experience over time
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- If your infusions need to occur during work hours, or if your child's infusions need to occur during school hours, you have decide to inform employers, teachers, or others about the importance of regular infusions
- Informing certain people about your infusions is an important decision and you may want to talk with your healthcare provider about it
- If you miss an infusion, talk to your doctor right away about rescheduling your appointment
- It may be necessary for you to plan ahead if you will be moving or traveling, so that you don’t miss an infusion
- Talk with your doctor or support services about the potential for arranging for treatment at your destination
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- If you are on Cerezyme and are pregnant or thinking of becoming pregnant, be sure to talk to your doctor
- There may be risks associated with staying on Cerezyme during pregnancy
- Be sure to tell your doctor if you are breastfeeding
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- Treatment with Cerezyme does not mean you should stop all daily activities
- If an opportunity arises for you to take a vacation, go to camp, attend college, or make a permanent move, talk to your doctor about developing a plan for treatment while you are away
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How Can Cerezyme Help?
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Get Support
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CNS=central nervous system; ERT=enzyme replacement therapy.
Important Safety Information
WARNING: SEVERE ALLERGIC REACTIONS
Allergic reactions, including severe reactions that may be serious or life-threatening (known as anaphylaxis), have occurred during the early course and after repeated treatment with CEREZYME.
Your healthcare professional should initiate CEREZYME in a healthcare setting with appropriate medical monitoring and support measures. If a severe allergic or anaphylactic reaction occurs, your healthcare professional will immediately stop the infusion and provide appropriate medical treatment.
Seek immediate medical care should symptoms occur.
Cerezyme can cause serious side effects including:
Allergic Reactions (Including Anaphylaxis) and Infusion-Associated Reactions (IARs):
Signs of an allergic reaction reported during or shortly after an infusion included itching, flushing, hives, swelling under the skin, chest discomfort, shortness of breath, coughing, a bluish discoloration of the skin due to diminished oxygen, rapid heart rate, and low blood pressure.
Signs of an infusion reaction included rash, chills, fatigue, infusion-site burning, infusion-site discomfort, or infusion-site swelling, fever, and high blood pressure. Tell your healthcare professional right away if you experience any reactions. Your healthcare professional may slow or stop the infusion or may lower the next dose. Your healthcare professional may decide to give you antihistamine, anti-fever, and/or steroid medications before your infusions and monitor you for new signs and symptoms of a reaction.
Common Side Effects:
- Common side effects reported in adults and children include back pain, chills, dizziness, fatigue, headache, allergic reactions, nausea, fever, and vomiting.
Please see accompanying Full Prescribing Information, including Boxed WARNING.
Cerezyme® (imiglucerase) for injection is indicated for the treatment of non-central nervous system (CNS) manifestations of Type 1 or Type 3 Gaucher disease in adult and pediatric patients.
Important Safety Information
WARNING: SEVERE ALLERGIC REACTIONS
Allergic reactions, including severe reactions that may be serious or life-threatening (known as anaphylaxis), have occurred during the early course and after repeated treatment with CEREZYME.
Your healthcare professional should initiate CEREZYME in a healthcare setting with appropriate medical monitoring and support measures. If a severe allergic or anaphylactic reaction occurs, your healthcare professional will immediately stop the infusion and provide appropriate medical treatment.
Seek immediate medical care should symptoms occur.
Cerezyme can cause serious side effects including:
Allergic Reactions (Including Anaphylaxis) and Infusion-Associated Reactions (IARs):
Signs of an allergic reaction reported during or shortly after an infusion included itching, flushing, hives, swelling under the skin, chest discomfort, shortness of breath, coughing, a bluish discoloration of the skin due to diminished oxygen, rapid heart rate, and low blood pressure.
Signs of an infusion reaction included rash, chills, fatigue, infusion-site burning, infusion-site discomfort, or infusion-site swelling, fever, and high blood pressure. Tell your healthcare professional right away if you experience any reactions. Your healthcare professional may slow or stop the infusion or may lower the next dose. Your healthcare professional may decide to give you antihistamine, anti-fever, and/or steroid medications before your infusions and monitor you for new signs and symptoms of a reaction.
Common Side Effects:
- Common side effects reported in adults and children include back pain, chills, dizziness, fatigue, headache, allergic reactions, nausea, fever, and vomiting.
Please see accompanying Full Prescribing Information, including Boxed WARNING.
Cerezyme® (imiglucerase) for injection is indicated for the treatment of non-central nervous system (CNS) manifestations of Type 1 or Type 3 Gaucher disease in adult and pediatric patients.
Important Safety Information
WARNING: SEVERE ALLERGIC REACTIONS
Allergic reactions, including severe reactions that may be serious or life-threatening (known as anaphylaxis), have occurred during the early course and after repeated treatment with CEREZYME.
Your healthcare professional should initiate CEREZYME in a healthcare setting with appropriate medical monitoring and support measures. If a severe allergic or anaphylactic reaction occurs, your healthcare professional will immediately stop the infusion and provide appropriate medical treatment.
Seek immediate medical care should symptoms occur.
Cerezyme can cause serious side effects including:
Allergic Reactions (Including Anaphylaxis) and Infusion-Associated Reactions (IARs):
Signs of an allergic reaction reported during or shortly after an infusion included itching, flushing, hives, swelling under the skin, chest discomfort, shortness of breath, coughing, a bluish discoloration of the skin due to diminished oxygen, rapid heart rate, and low blood pressure.
Signs of an infusion reaction included rash, chills, fatigue, infusion-site burning, infusion-site discomfort, or infusion-site swelling, fever, and high blood pressure. Tell your healthcare professional right away if you experience any reactions. Your healthcare professional may slow or stop the infusion or may lower the next dose. Your healthcare professional may decide to give you antihistamine, anti-fever, and/or steroid medications before your infusions and monitor you for new signs and symptoms of a reaction.
Common Side Effects:
- Common side effects reported in adults and children include back pain, chills, dizziness, fatigue, headache, allergic reactions, nausea, fever, and vomiting.
Please see accompanying Full Prescribing Information, including Boxed WARNING.
Cerezyme® (imiglucerase) for injection is indicated for the treatment of non-central nervous system (CNS) manifestations of Type 1 or Type 3 Gaucher disease in adult and pediatric patients.