Cerezyme is typically given by infusion for 1-2 hours every 2 weeks. Yourdoctor will determine your Cerezyme dose and frequency.
Cerezyme is an ERT (enzyme replacement therapy) designed to reduce the accumulation of a fatty substance called GL-1 in the spleen, liver, and bones. The build-up of GL-1 ultimately causes the signs and symptoms of Gaucher disease. Cerezyme has helped adults and children with Gaucher disease type 1 by improving key disease symptoms over the long term.
Studies show that Cerezyme treatment helped people with Gaucher disease type 1 by improving certain disease symptoms
As with any medicine, there may be potential side effects with Cerezyme. You should notify your doctor immediately if you experience any side effects while undergoing treatment with Cerezyme.
Cerezyme® (imiglucerase for injection) is indicated for long-term enzyme replacement therapy for pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions:
Approximately 15% of patients have developed immune responses (antibodies) to Cerezyme during the first year of therapy. These patients have a higher risk of an allergic reaction (hypersensitivity). Your doctor may periodically test for the presence of antibodies. Serious allergic reactions (anaphylaxis) have been reported in less than 1% of patients. Symptoms suggestive of allergic reaction happened in approximately 7% of patients, and include itching, flushing, hives, swelling, chest discomfort, shortness of breath, coughing, cyanosis (a bluish discoloration of the skin due to diminished oxygen), and low blood pressure. If you have had an allergic reaction to Cerezyme, you and your doctor should use caution if you continue to receive treatment with Cerezyme.
High blood pressure in the arteries of the lungs (pulmonary hypertension) and pneumonia have been observed in less than 1% of patients during treatment with Cerezyme. These are also known complications of Gaucher disease regardless of treatment. If you experience symptoms such as shortness of breath or chest pain, with or without fever, contact your doctor.
Approximately 14% of patients have experienced side effects related to treatment with Cerezyme. Some of these reactions occur at the site of injection such as discomfort, itching, burning, swelling or uninfected abscess. Other side effects, each of which was reported by less than 2% of patients, include nausea, abdominal pain, vomiting, diarrhea, rash, fatigue, headache, fever, dizziness, chills, backache, and rapid heart rate. Temporary swelling in the legs has also been observed with drugs like Cerezyme.
Please see Full Prescribing Information (PDF).